The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. When dietary intake of cholesterol is high, synthesis. Cholesterol synthesis: Hydroxymethylglutaryl-coenzyme A (HMG-CoA) is the precursor for cholesterol synthesis. HMG-CoA is also an intermediate on the pathway. Learn more about cholesterol metabolism in the Boundless open textbook. Regulation of Blood Cholesterol Levels. Next Concept Create Question. Transcriptional regulation of cholesterol synthesis starts in the ER; When cholesterol is low, SREBP is sorted to the Golgi apparatus; Proteolytic cleavage in the. Cholesterol synthesis- Details of steps, regulation, transport of cholesterol, variations of serum cholesterol levels, hypolipidemic drugs.
Abstract. Coordinate regulation of the cytosolic synthase and microsomal reductase for hydroxymethylglutaryl-CoA occurs rapidly and is primarily at the level of mRNA.